

Common Side Effects
- Animation
- Drama
- Comedy
- Sci-Fi & Fantasy
Former high school lab partners Marshall and Frances begin to unravel a conspiracy involving big pharma and the federal government to suppress knowledge of a rare mushroom that may hold the key to curing all the world’s diseases.
Common Side Effects is an animated sci-fi comedy-drama that premiered on February 2, 2025. The series follows former high school lab partners Marshall and Frances as they uncover a conspiracy involving big pharma and federal government efforts to suppress knowledge of a rare mushroom with potential to cure all diseases.
When does Common Side Effects come out?
Where to watch
Streaming availability in United States
Availability varies by country. A VPN can let you watch content licensed in another region, though most streaming services prohibit it in their terms of service. Use at your own discretion. Contains affiliate links.
Rent or buy
Digital purchase & rental in United States
Where to watch Common Side Effects by country
Top cast
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Dave KingMarshall Cuso (voice)
Emily PendergastFrances Applewhite (voice)
Mike JudgeRick Kruger (voice)
Martha KellyAgent Harrington (voice)
Joseph Lee AndersonAgent Copano (voice)
Alan ResnickZane (voice)
Lin ShayeSonia (voice)
Shalita GrantSusan (voice), Kelly (voice), Female DEA Agent (voice), Oncologist (voice)
Andy DalyMysterious Passenger (voice), Christopher (voice)
Bob StephensonSamurai (voice), Line Guy 2 (voice), Connor (voice)
Timothy SimonsDEA Dispatcher (voice), Lawyer (voice), Test Subject 3 (voice)
Nicolas CantuTommy (voice)- Jon FoorHoang (voice)
Sydney Tamiia PoitierCecily (voice)- Sue RoseHildy (voice)
Trailer
Official Trailer [Adult Swim Europe]
Seasons
2 seasonsRelated & spin-offs
Other titles fans of Common Side Effects tend to follow.
Is Common Side Effects renewed or cancelled?
Common Side Effects is listed as ongoing — no renewal announcement tracked yet.
Common Side Effects — frequently asked
When did Common Side Effects premiere?
The series premiered on February 2, 2025.
How many seasons of Common Side Effects are there?
Two seasons of Common Side Effects have been tracked, though specific episode counts and availability details are not confirmed.
What is Common Side Effects about?
The show follows Marshall and Frances, former lab partners from high school, as they investigate a conspiracy by pharmaceutical companies and the government to hide the existence of a rare mushroom that may cure all diseases.
What genres does Common Side Effects blend?
Common Side Effects combines animation with drama, comedy, and sci-fi and fantasy elements.


















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