Season 2

Shinoa spars against Guren before visiting Yu in the library. She tells him about turning humans into vampires. Then, Kureto Hiragi summons Yu to ask him about a vampire spy while torturing Kimizuki and Yoichi to make him tell the truth. Afterward, Yu asks Guren about it and asks if Mika would also be useful to him. In Sanguinem, Mika starves for blood and Ferid recommends halting his growth there. A child offers his blood to Ferid, and Ferid tempts Mika to drink the boy's blood but Mika refuses. Ferid then invites Mika to the Progenitor Council meeting.

Yoichi eliminates five horsemen with one attack, and Yu begins the next step of his training. Yu battles against Asuramaru in his mind and defeats Asuramaru by asking to become friends. At the Progenitor Council meeting, Ferid discusses the battle at Shinjuku and has Mika present a video showing Yu's transformation. Krul strikes at Ferid and intentionally misses. Ferid explains that she cannot kill him. Kimizuki struggles in battle against Kiseki-o and faces memories where he was told to kill his sister. He breaks free and is victorious by remembering Yu's feelings for Mika, who are family even though they are not related by blood. Kimizuki and Yu show off their new techniques, and Shinoa and Mitsuba learn the files on the three boys have been erased.

The child who contacted Ferid Bathory in the previous episode sends a letter via messenger pigeon to Aoi Sangu, who passes it on to Kureto. Shinoa Squad meets, and Kureto Hiragi and Guren Ichinose do the same. Kureto announces his plan to attack and wipe out ten noble vampires in Nagoya before the vampires bring their main army down on Japan in one month. Shinoa reveals that Yu tried to kill her during the battle in Shinjuku, and the squad considers whether to keep following Guren or not. Eventually, they decide to follow him and make their policy to protect their family. Meanwhile, Mika attacks Krul for her blood. Once he calms down, she reveals her plans to him and gives him a secret mission. Shinoa briefs Guren on her squad's success in training, and he gives her new orders. Mika meets with other vampires to head to Nagoya, and Kureto orders potentially lethal experimentation on Mirai Kimizuki.

When the Shinoa squad arrives late, they realize just how serious this mission is for Guren. Knowing this is an impossible mission where many will die, Guren puts his emotions aside and orders his men to not necessarily survive, but to win.

The Shinoa squad and Narumi squad join forces to carry out their mission - to kill the Fifteenth Progenitor, Lucal Wesker. While they succeed in their mission without losing anybody, others were not so lucky. Nine teams fail and were taken as hostages...

The Shinoa squad re-learns the hard cold fact that it's very possible to lose comrades, but there's no time to mourn. They must move on to go rescue the hostages. Right after their departure, Mika and the other vampires arrive to Nagoya as well.

Guren, Shinoa, and Narumi squads arrive at the city hall and see the hostages. Knowing it's a set-up, they still decide to go save the hostages, but Guren and Shinya are way over their heads with Crowley, as they struggle just to run away from him.

Shinoa's squad goes to save Guren, but unfortunately, they run out of time. Reluctantly, they leave him behind and retreat, but Yu just cannot bring himself to do that. Instead, he takes more of the Curse Stimulant Pills to go save Guren himself.

Thanks to his "experimentation," Yu makes a miraculous recovery and once again, goes back to save Guren. Pushing too hard, Yu nearly becomes a demon, but Kimizuki stops him by force. The squad carries Yu out and heads for safety, but then encounters Mika.

Yu and Mika are finally reunited, but the injuries Mika had sustained from fighting the Demon Company threatens his life. Determined to keep Mika alive, Yu tries to persuade Mika into drinking his blood... Even if it means Mika will become a true vampire.

The survivors of the Moon Demon Company get to the rendezvous point, only to find out that their orders are to "standby." Enraged, they decide to ignore the orders to save Guren, when Kureto appears. Apparently, Kureto has something else on the agenda.

Kureto's trump card was Mirai, Kimizuki's younger sister and another Seraph of the End test subject. In order to stop the Japanese Imperial Demon Army, Yu has no choice but to reach out to his inner "trumpet" to tap into the angel's powers.